Public Health Rev. Is ignorance bliss? Depression, antidepressants, and the diagnosis of prediabetes and type 2 diabetes. Health Psychol. Pioglitazone for diabetes prevention in impaired glucose tolerance [published corrections appear in N Engl J Med.
Dipeptidyl-peptidase DPP -4 inhibitors and glucagon-like peptide GLP -1 analogues for prevention or delay of type 2 diabetes mellitus and its associated complications in people at increased risk for the development of type 2 diabetes mellitus.
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You don't need to wait to take it. People who made major lifestyle changes were compared with people who took metformin or a placebo and got information about lifestyle changes for type 2 diabetes. Making major lifestyle changes or taking metformin both work better than a placebo pill at delaying or preventing type 2 diabetes.
For many people, making major lifestyle changes works better than taking metformin to help delay or prevent type 2 diabetes for up to 10 years. Let's compare people who made major lifestyle changes versus people who took metformin. These numbers apply to many people. But for some people, either making major lifestyle changes or taking metformin works very well to delay or prevent type 2 diabetes.
This seems to be especially true for:. Many people age 60 and older benefit more from making major lifestyle changes. And many people younger than 60 benefit more from taking metformin. Making major lifestyle changes or taking metformin both work better than a placebo pill at delaying or preventing type 2 diabetes in women who have had gestational diabetes for up to 3 years. But a follow-up study at 10 years showed that taking metformin works a little better than making major lifestyle changes in helping to delay or prevent type 2 diabetes.
Let's compare women who've had gestational diabetes who either made major lifestyle changes or who took metformin. About 20 out of women who made major lifestyle changes got type 2 diabetes. Compare that to about 22 out of women who took metformin and got type 2 diabetes. That means 2 fewer women got type 2 diabetes after 3 years with lifestyle changes than with metformin. About 56 out of women who made major lifestyle changes got type 2 diabetes.
Compare that to about 51 out of women who took metformin and got type 2 diabetes. That means 5 more women got type 2 diabetes after 10 years with lifestyle changes than with metformin. Some evidence is better than other evidence.
Evidence comes from studies that look at how well treatments and tests work and how safe they are. For many reasons, some studies are more reliable than others. The better the evidence is—the higher its quality—the more we can trust it. The information shown here is based on the best available evidence. Another thing to understand is that the evidence can't predict what's going to happen in your case. When evidence tells us that 2 out of people who have a certain test or treatment may have a certain result and that 98 out of may not, there's no way to know if you will be one of the 2 or one of the The ADA also suggests taking metformin, especially if you're younger than 60, have a body mass index BMI of 35 or more, or have had gestational diabetes.
The ADA recommends that you and your doctor talk about the benefits and risks of making lifestyle changes or using metformin to prevent type 2 diabetes and to make a decision based on your personal preferences and overall health. These stories are based on information gathered from health professionals and consumers. They may be helpful as you make important health decisions.
I had gestational diabetes with my last child. I know this puts me at risk for getting type 2 diabetes later on, so I want to do whatever I can to prevent that from happening. My gym offers a diabetes prevention program, and I'm going to sign up for it.
I try to eat healthy and exercise, but I think having more information and support will really help. I knew I had to do something when I found out I had prediabetes. My mom had diabetes, and I know what it's like. So I'm really going to work on it. I'm going to set goals for weight loss and exercise. And I want to see a dietitian. I'm confused about what to eat and the best way to lose weight. I'm not sure what to do about prediabetes, but I know I have to do something.
I think I'll start with metformin and also try the lifestyle changes. That way, if I'm not great at making changes, I know medicine will help me. I'm an active guy, but I know I've got some extra weight. I've tried to lose weight before. But knowing I might get diabetes makes it really important that I lose weight.
And my whole family is going to help by making some changes in how we eat. I hope that with everyone's support I can lose the weight and not have to think about using metformin. I tried lifestyle changes, but I didn't feel I was doing too well with them. I just couldn't find the time for exercise. I don't want to get diabetes, so I'm taking medicine every day.
Maybe when things settle down, I'll try to make changes again. Your personal feelings are just as important as the medical facts. Think about what matters most to you in this decision, and show how you feel about the following statements.
If I can avoid type 2 diabetes by using medicine, I'll deal with any side effects. Now that you've thought about the facts and your feelings, you may have a general idea of where you stand on this decision. Show which way you are leaning right now.
How sure do you feel right now about your decision? Here's a record of your answers. You can use it to talk with your doctor or loved ones about your decision. Studies show that making these three major lifestyle changes make getting type 2 diabetes less likely: 3. Are there things you can do to help prevent type 2 diabetes? Does either making major lifestyle changes or taking metformin work well to prevent type 2 diabetes?
Are you clear about which benefits and side effects matter most to you? Do you have enough support and advice from others to make a choice? Author: Healthwise Staff. This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use.
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Updated visitor guidelines. Get the facts. Your options Make major lifestyle changes to help prevent type 2 diabetes. Take the medicine metformin Glucophage to help prevent type 2 diabetes.
Key points to remember If you have prediabetes, your blood sugar is higher than it should be. You are more likely to get type 2 diabetes. Major lifestyle changes can help prevent type 2 diabetes in people with prediabetes. These changes include losing weight, eating healthier foods, and getting more exercise.
The medicine metformin can also help prevent type 2 diabetes in people with prediabetes. Even if you take metformin, it is important to make as many healthy lifestyle changes as you can. What is prediabetes? Why should you avoid type 2 diabetes? How do you prevent type 2 diabetes? Since then, while the number of Americans with prediabetes has increased from 79 million to over 84 million one in three US adults , the FDA has not approved metformin for prediabetes — primarily because no organizations have submitted it for approval.
Prediabetes is marked by elevated glucose levels or an A1C of 5. Accordingly, experts predict that by , one in four adults will have type 2 diabetes. Fortunately, there are ways to prevent or delay progression of prediabetes. Metformin is virtually always the first medication prescribed for type 2 patients because it has few side effects and a low cost. Metformin is a well-studied, generic drug, and with the proper dosage training for health care providers, it has great potential to be used by a variety of people.
Because not all people with prediabetes will develop diabetes, many experts recommend prescribing metformin only to those at the higher end of the risk spectrum. Based on data from DPP, the American Diabetes Association recommends metformin for people under the age of 60, with a BMI greater than 35, or with a history of gestational diabetes — and especially for people whose rising blood glucose levels do not respond to major lifestyle changes.
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